587 research outputs found

    Looking on the bright side of life: Gratitude and experiences of interpersonal transgressions in adulthood and daily life

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    OBJECTIVE: Gratitude plays an important role in individual and social well-being. However, less is known about the link between gratitude and experiences of interpersonal stressors. The current research examined the associations between gratitude and interpersonal transgressions. METHOD: One cross-sectional study with a broad age range and two daily diary studies (total N = 2,348; total age range: 18-91) were used to test the associations on the between- and within-person level. RESULTS: A consistent result across all studies was that dispositionally grateful individuals tended to report fewer interpersonal transgressions than less grateful people. In turn, people who generally reported more interpersonal transgressions were less grateful in daily life. Moreover, higher gratitude on one specific day was associated with fewer reported transgressions on the same day. However, the results from the daily diary studies indicated differences between the samples. Whereas gratitude was consistently associated with interpersonal transgressions in one daily diary sample, the findings in the second daily diary sample were less consistent. CONCLUSION: The present findings suggest that grateful people tend to perceive their social exchanges differently and/or actually experience fewer interpersonal transgressions. Future work is needed to test the underlying mechanisms of this negative association

    Control of Pre-mRNA Splicing by the General Splicing Factors PUF60 and U2AF65

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    Pre-mRNA splicing is a crucial step in gene expression, and accurate recognition of splice sites is an essential part of this process. Splice sites with weak matches to the consensus sequences are common, though it is not clear how such sites are efficiently utilized. Using an in vitro splicing-complementation approach, we identified PUF60 as a factor that promotes splicing of an intron with a weak 3' splice-site. PUF60 has homology to U2AF(65), a general splicing factor that facilitates 3' splice-site recognition at the early stages of spliceosome assembly. We demonstrate that PUF60 can functionally substitute for U2AF(65)in vitro, but splicing is strongly stimulated by the presence of both proteins. Reduction of either PUF60 or U2AF(65) in cells alters the splicing pattern of endogenous transcripts, consistent with the idea that regulation of PUF60 and U2AF(65) levels can dictate alternative splicing patterns. Our results indicate that recognition of 3' splice sites involves different U2AF-like molecules, and that modulation of these general splicing factors can have profound effects on splicing

    Biological status and dietary intakes ofiIron, zinc and vitamin A among women and preschool children in rural Burkina Faso

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    Background Food-based approaches such as biofortification are meant to sustainably address micronutrient deficiencies in poor settings. Knowing more about micronutrient intakes and deficiencies is a prerequisite to designing and evaluating interventions. Objective The objectives of the study were to assess biological status and dietary intakes of iron, zinc and vitamin A among women and children aged 36-59 months in rural Burkina Faso and to study relationships between intake and status to better inform future food-based interventions. Design A cross-sectional survey was carried out in two rural provinces of Burkina Faso on a random cluster sample of 480 mother-child pairs. Dietary data was obtained by 24-hour recalls repeated on a random sub-selection of 37.5% of subjects to allow calculation of nutrient's probability of adequacy (PA). Biomarkers were measured on a sub-sample of 180 mother-child pairs. Blood samples were analyzed for hemoglobin, serum ferritin, soluble transferrin receptors (sTfR), C-reactive protein, alpha-1-glycoprotein, serum zinc concentration (SZnC) and retinol. For each micronutrient the relationship between biomarker and dietary intake was investigated by multiple linear regression models accounting for inflammatory biomarkers. Results Mean PA for iron, zinc and vitamin A was 0.49, 0.87 and 0.21 among women and 0.61, 0.95 and 0.33 among children, respectively. Prevalence of anemia, corrected low serum ferritin and high sTfR was 37.6%, 4.0% and 77.5% among women and 72.1%, 1.5% and 87.6% among children, respectively. Prevalence of low SZnC and corrected low serum retinol was 39.4% and 12.0% among women and 63.7% and 24.8% among children, respectively. There was a tendency for a positive relationship between vitamin A intakes and serum retinol among women (beta = 0.0003, P = 0.06). Otherwise, no link was found between micronutrients biomarkers and intakes. Conclusion Our study depicted different images of micronutrient deficiencies when based on dietary intakes or biomarkers results, thus highlighting the need for more suitable biomarkers and more precise measures of absorbable micronutrient intakes at the individual level. It thus points to challenges in the design and evaluation of future biofortification or other food-based interventions in rural areas of Burkina Faso

    Critical exponents at the ferromagnetic transition in tetrakis(diethylamino)ethylene-C60_{60} (TDAE-C60_{60})

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    Critical exponents at the ferromagnetic transition were measured for the first time in an organic ferromagnetic material tetrakis(dimethylamino)ethylene fullerene[60] (TDAE-C60_{60}). From a complete magnetization-temperature-field data set near Tc=16.1±0.05,T_{c}=16.1\pm 0.05, we determine the susceptibility and magnetization critical exponents γ=1.22±0.02\gamma =1.22\pm 0.02 and β=0.75±0.03\beta =0.75 \pm 0.03 respectively, and the field vs. magnetization exponent at TcT_{c} of δ=2.28±0.14\delta =2.28\pm 0.14. Hyperscaling is found to be violated by Ω≡d′−d≈−1/4\Omega \equiv d^{\prime}-d \approx -1/4, suggesting that the onset of ferromagnetism can be related to percolation of a particular contact configuration of C60_{60} molecular orientations.Comment: 5 pages, including 3 figures; to appear in Phys. Rev. Let

    The polymer phase of the TDAE-C60_{60} organic ferromagnet

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    The high-pressure Electron Spin Resonance (ESR) measurements were preformed on TDAE-C60_{60} single crystals and stability of the polymeric phase was established in the P−TP - T parameter space. At 7 kbar the system undergoes a ferromagnetic to paramagnetic phase transition due to the pressure-induced polymerization. The polymeric phase remains stable after the pressure release. The depolymerization of the pressure-induced phase was observed at the temperature of 520 K. Below room temperature, the polymeric phase behaves as a simple Curie-type insulator with one unpaired electron spin per chemical formula. The TDAE+^+ donor-related unpaired electron spins, formerly ESR-silent, become active above the temperature of 320 K and the Curie-Weiss behavior is re-established.Comment: Submitted to Phys. Rev.

    Live Tissue Imaging Shows Reef Corals Elevate pH under Their Calcifying Tissue Relative to Seawater

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    The threat posed to coral reefs by changes in seawater pH and carbonate chemistry (ocean acidification) raises the need for a better mechanistic understanding of physiological processes linked to coral calcification. Current models of coral calcification argue that corals elevate extracellular pH under their calcifying tissue relative to seawater to promote skeleton formation, but pH measurements taken from the calcifying tissue of living, intact corals have not been achieved to date. We performed live tissue imaging of the reef coral Stylophora pistillata to determine extracellular pH under the calcifying tissue and intracellular pH in calicoblastic cells. We worked with actively calcifying corals under flowing seawater and show that extracellular pH (pHe) under the calicoblastic epithelium is elevated by ∼0.5 and ∼0.2 pH units relative to the surrounding seawater in light and dark conditions respectively. By contrast, the intracellular pH (pHi) of the calicoblastic epithelium remains stable in the light and dark. Estimates of aragonite saturation states derived from our data indicate the elevation in subcalicoblastic pHe favour calcification and may thus be a critical step in the calcification process. However, the observed close association of the calicoblastic epithelium with the underlying crystals suggests that the calicoblastic cells influence the growth of the coral skeleton by other processes in addition to pHe modification. The procedure used in the current study provides a novel, tangible approach for future investigations into these processes and the impact of environmental change on the cellular mechanisms underpinning coral calcification

    Identity development and forgivingness: tests of basic relations and mediational pathways

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    Adaptive identity development leads to increases in personality traits that allow for social well-being. The current study tested this claim with respect to forgivingness, a dispositional tendency to forgive others. In a sample of university undergraduates (N = 214), we examined the relations between forgivingness and two indicators of identity development: commitment and exploration. Forgivingness uniquely positively related with both identity variables, controlling for the other. Next, we tested mediational models to examine the mechanisms underlying these relationships. Our results suggest that, in part, the association between identity development and forgivingness is mediated by levels of agreeableness and neuroticism, as measured by the Big Five Inventory

    Entrepreneurs’ age, institutions, and social value creation goals: a multi-country study

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    This study explores the relationship between an entrepreneur's age and his/her social value creation goals. Building on the lifespan developmental psychology literature and institutional theory, we hypothesize a U-shaped relationship between entrepreneurs’ age and their choice to create social value through their ventures, such that younger and older entrepreneurs create more social value with their businesses while middle age entrepreneurs are relatively more economically and less socially oriented with their ventures. We further hypothesize that the quality of a country’s formal institutions in terms of economic, social, and political freedom steepen the U-shaped relationship between entrepreneurs’ age and their choice to pursue social value creation as supportive institutional environments allow entrepreneurs to follow their age-based preferences. We confirm our predictions using multilevel mixed-effects linear regressions on a sample of over 15,000 entrepreneurs (aged between 18 and 64 years) in 45 countries from Global Entrepreneurship Monitor data. The findings are robust to several alternative specifications. Based on our findings, we discuss implications for theory and practice, and we propose future research directions

    Contrasting futures for ocean and society from different anthropogenic CO2 emissions scenarios

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    The ocean moderates anthropogenic climate change at the cost of profound alterations of its physics, chemistry, ecology, and services. Here, we evaluate and compare the risks of impacts on marine and coastal ecosystems and the goods and services they provide for growing cumulative carbon emissions under two contrasting emissions scenarios. The current emissions trajectory would rapidly and significantly alter many ecosystems and the associated services on which humans heavily depend. A reduced emissions scenario consistent with the Copenhagen Accord’s goal of a global temperature increase of less than 2°C—is much more favorable to the ocean but still substantially alters important marine ecosystems and associated goods and services. The management options to address ocean impacts narrow as the ocean warms and acidifies. Consequently, any new climate regime that fails to minimize ocean impacts would be incomplete and inadequate
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